Tuesday, December 11, 2012

Stevia Stock Alert: Sunwin Stevia International, Inc. (OTCQB: SUWN) Gains New Coverage as Industry Ramps Up

POINT ROBERTS, WA - December 11, 2012 (Investorideas.com Newswire) Investorideas.com staff: Investorideas.com, an investor research portal specializing in sector research for independent investors, issues a news and media alert for agriculture stevia stock, Sunwin Stevia International, Inc. (OTCQB:SUWN). Sunwin has gained momentum with food industry media and investment media as it ramps up for the anticipated global demand as new regulatory approvals increase markets.

Sunwin Stevia was featured in a SeekingAlpha.com in an article today entitled," Companies Gear Up As Health Canada Approves Stevia As Additive For Food And Beverage Use “. Author Glen S. Woods notes," Given the continued expansion of stevia globally, Sunwin may well be one of those small companies that may benefit shareholders with impressive stock gains if its success continues."
The Company was also featured in BakeryandSnacks.com November 30 th and FoodProductionDaily.com December 5 th. (see below)
Summary of Coverage:
Sunwin (OTCQB: SUWN) on SeekingAlpha.com - Companies Gear Up As Health Canada Approves Stevia As Additive For Food And Beverage Use
December 11, 2012 by: Glen S. Woods | includes: MNST, STVF.OB, SUWN.OB
http://seekingalpha.com/article/1056111-companies-gear-up-as-health-canada-approves-stevia-as-additive-for-food-and-beverage-use
Excerpt from article:
Sunwin Stevia International (SUWN.OB), based in Qufu, China, a vertically-integrated manufacturer of stevia products and traditional Chinese medicines, announced the installation of new high-tech production lines to expand its stevia production capacity to 1,300 metric tons, including 500 metric tons of high-grade stevioside Rebaudioside A (Reb A), and 500 metric tons of steviosin, a stevioside extract used by the pharmaceutical industry. Sunwin began its expansion project in April anticipating an improvement in demand for stevia as a healthy low calorie sweetener and is now poised to capitalize on the industry's upward trend. With Canada's approval of stevia, it becomes apparent that the company was correct as stevia continues to grow in worldwide acceptance. Sunwin's new stevioside extraction line uses a state-of-the-art crystallization process that substantially reduces the production time while increasing product yield leading to a substantial reduction in overall processing costs as utilization rates increase. Sunwin has begun trial production of its new lines and anticipates its added production capabilities to be fully operational in the first quarter of 2013.
In August Sunwin entered into a worldwide stevia distribution agreement with WILD Flavors, giving WILD a non-exclusive worldwide right as a distributor to market and resell all Sunwin stevia products. Sunwin is also developing 6 new formulations in conjunction with WILD with the goal of penetrating the $10.3 billion Chinese bakery market by marketing to manufacturers to develop private label products - a move that the company sees will bolster its domestic production base in China.
Sunwin, with a market cap of $45.1 million, has had an impressive 3-month run, up 30% to $0.27 per share, but still off its 52-week high of $0.35 per share. In the past week of trading, its volume has risen to an average of 41,000 shares traded daily. I like the aggressiveness of Sunwin, and its timing appears to be spot on, especially with Canada's announcement last week. Given the continued expansion of stevia globally, Sunwin may well be one of those small companies that may benefit shareholders with impressive stock gains if its success continues
Sunwin Stevia pours cash into production
FoodProductionDaily.com - December 5, 2012
Sunwin Stevia International has invested heavily in production capacity to support declared growth plans in China.
http://www.foodproductiondaily.com/Processing/Sunwin-Stevia-pours-cash-into-production
Sunwin to broaden stevia presence through Chinese private label bakery
By Kacey Culliney November 30 th- BakeryandSnacks.com
Sunwin Stevia International hopes to penetrate the Chinese bakery sector further by targeting the private label segment with a range of stevia formulations
http://www.bakeryandsnacks.com/Formulation/Sunwin-to-broaden-stevia-presence-through-Chinese-private-label-bakery
About Sunwin Stevia International, Inc.
Sunwin Stevia International, Inc. engages in the areas of zero calorie, all natural sweeteners (Sunwin Stevia™ Extracts). As an industry leader in agricultural processing, Sunwin has built an integrated global firm with the sourcing and production capabilities to meet the needs of consumers throughout the world. For more info about Sunwin, please visit http://www.sunwininternational.com
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Monday, December 10, 2012

Stevia; A Solution in the Battle Against Diabetes and Obesity

POINT ROBERTS, WA - December 10, 2012 (Investorideas.com Newswire) Investorideas.com, an investor research portal specializing in sector research for independent investors issues a sector snapshot for stevia stocks/agriculture stocks and the role stevia may play in the potential battle against diabetes and obesity, as a natural replacement to sugar.

An article today in Theage.com noted "Stevia has been said, by many, to be the sweet solution to the sugar 'problem'. Native to Paraguay, the stevia plant is as much as 300 times sweeter than sugar, but has barely any effect on blood glucose levels and contains no calories.
It's pitched as the 'natural' alternative to artificial sweeteners and is the choice of US physicist and renowned sugar critic, Gary Taubes, who has said that by spiking our insulin levels, sugar, not fat, is responsible for the obesity epidemic and a slew of related illnesses."
Lauren Bandy, an Ingredients Research Analyst with Euromonitor International, recently said "Stevia offers food and beverage manufacturers a way to reduce the sugar content of their products in a more natural way. Health and wellness is a key trend in the food and beverage sector and stevia is perfectly positioned to capitalize on the growth of the better-for-you market."
Euromonitor forecast that stevia will have an annual growth rate of 23% globally over 2011-2016, in volume terms.
Publicly traded stevia stocks to watch include:
Sunwin Stevia International, Inc. (OTCQB: SUWN) engages in the areas of zero calorie, all natural sweeteners (Sunwin Stevia™ Extracts). As an industry leader in agricultural processing, Sunwin has built an integrated global firm with the sourcing and production capabilities to meet the needs of consumers throughout the world. The Company has partnered with WILD Flavors GmbH, based in Zug, Switzerland, one of the world's leading privately-owned manufacturers of natural ingredients for the food and beverage industry. WILD's Sunwin Stevia™ brand provides beverage manufacturers one-source solutions: high-quality Stevia extracts in varying Reb Alevels plus WILD's natural Taste Optimization Technology.
S&W Seed Company (Nasdaq: SANW), founded in 1980 and headquartered in the Central Valley of California, is a leading producer of warm climate, high yield alfalfa seed varieties, including varieties that can thrive in poor, saline soils, as verified over decades of university-sponsored trials. S&W Seed also offers seed cleaning and processing at its 40-acre facility in Five Points, California and, in 2011, began the commercial launch of its California-based stevia leaf business in response to the growing global demand for the all-natural, zero calorie sweetener from the food and beverage industry.
Ingredion Incorporated (NYSE:INGR) is a leading global ingredients solutions provider specializing in nature-based sweeteners, starches and nutrition ingredients (including stevia). With customers in more than 40 countries, Ingredion, formerly Corn Products International, serves approximately 60 diverse sectors in food, beverage, brewing, pharmaceuticals and other industries
PureCircle Limited (LSE: PURE.L) is the world's leading producer of high purity stevia ingredients for the global food and beverage industry. As the driving force behind moving stevia from niche to mainstream global acceptance, we are changing the conversation around sweet for manufacturers as well as consumers
Article source: http://www.theage.com.au/lifestyle/diet-and-fitness/the-sweet-solution-20121210-2b4bv.html
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Tech Stocks Investor Research Update for Mobile Security Stocks and Mobile App Stocks

New York, New York - December 10, 2012 (Investorideas.com newswire, www.techsectorstocks.com) Investorideas.com staff: Investorideas.com, an investor research portal specializing in sector research for independent investors issues new research and directories for the tech sector including a list of publicly traded mobile security stocks and mobile app stocks.

Mobile Security Stocks
Accenture ( NYSE:ACN) is a global management consulting, technology services and outsourcing company, with approximately 257,000 people serving clients in more than 120 countries. Combining unparalleled experience, comprehensive capabilities across all industries and business functions, and extensive research on the world's most successful companies, Accenture collaborates with clients to help them become high-performance businesses and governments. Mobile SecurityWebcast: http://www.accenture.com/us-en/Pages/insight-mobile-security-webcast-cio.aspx
AT&T Inc. ( NYSE:T) together with its subsidiaries, provides telecommunications services to consumers, businesses, and other providers worldwide. The company's Wireless segment offers wireless voice and data communication services, such as local wireless communications services, long-distance services, and roaming services. This segment also sells various handsets, wirelessly enabled computers, and personal computer wireless data cards; and accessories, including carrying cases, hands-free devices, batteries, battery chargers, and other items. This segment sells its products through its own stores, or through agents or third-party retail stores. Its Wireline segment provides data services comprising switched and dedicated transport, Internet access and network integration, U-verse services, and data equipment; businesses voice applications over IP-based networks; and digital subscriber lines, dial-up Internet access, private lines, managed Web-hosting services, packet services, enterprise networking services, and Wi-Fi services, as well as local, interstate, and international wholesale networking capacity to other service providers. This segment also offers voice services, such as local and long-distance, calling card, 1-800, conference calling, wholesale switched access, caller ID, call waiting, and voice mail services; and application management, security services, integration services, customer premises equipment, outsourcing, government-related services, and satellite video services. The company's Advertising Solutions segment publishes yellow and white pages directories; and sells directory advertising and Internet-based advertising and local search. In addition, the company provides customer information services. Mobile Security Products: http://www.att.com/gen/press-room?pid=22741
Elephant Talk Communications, Inc. ( NYSE MKT: ETAK) is a leading international provider of mobile networking software and services. The Company's mission is to provide a single service, fully enabling and securing the mobile cloud. Elephant Talk empowers Mobile Network Operators (MNOs) and Mobile Virtual Network Operators (MVNOs) by providing a cloud based mobile communications infrastructure, operating software and managed services, based mostly on company developed and owned software. We enable these Mobile Operators and Virtual Network Operators by offering a full suite of products, delivery platforms, support services, superior industry expertise and high quality customer service without substantial upfront investment. As a specialized outsourcing partner, we provide operating software, managed services, cloud and SaaS solutions, an integrated transaction and delivery platform to the mobile telecommunications industry globally. Our products include remote health care, credit card fraud prevention, mobile internet ID security, secure remote file access management, loyalty and transaction management services and a whole range of other emerging mobile services.  Elephant Talk can count several of the world's leading Mobile Operators amongst their customers including Vodafone, T-Mobile and Zain, and virtually all business is focused on tier 1 operators worldwide.
Microsoft Corp. ( NasdaqGS:MSFT) develops, licenses, and supports software products and services; and designs and sells hardware worldwide. The company's Windows & Windows Live division offers PC operating system that primarily includes Windows 7 operating system, Windows live suite of applications and Web services, and PC hardware products. Its Server and Tools division provides Windows Server operating systems, Windows Azure; Microsoft SQL Server, SQL Azure, Windows Intune, Windows Embedded, Visual Studio, Silverlight, system center products, Microsoft consulting services, and Premier product support services. This division also offers cloud-based services; and training and certification to developers and information technology professionals, as well as builds standalone and software development lifecycle tools for software architects, developers, testers, and project managers. The company's Online Services division provides online information and content, including Bing, MSN, adCenter, and Atlas online tools for advertisers. Its Microsoft Business division offers Microsoft office, Microsoft Exchange, Microsoft SharePoint, Microsoft Lync, Microsoft Office project and office Visio, and Microsoft Dynamics ERP and CRM, as well as Microsoft Office Web Apps and Microsoft Office 365, which are online service offerings. The company's Entertainment and Devices Division segment provides Xbox 360 entertainment platform, which includes the Xbox 360 gaming and entertainment console, Kinect for Xbox 360, Xbox 360 video games, and Xbox 360 accessories; Xbox LIVE; Skype; and Windows Phone. Microsoft Corporation markets and distributes its products and services primarily through original equipment manufacturers, distributors, and resellers, as well as through online. The company has strategic alliances with Nokia, and NIIT Ltd., as well as a strategic relationship Dominion Enterprises, Inc. Mobile Security: Device Security Manager helps developers test various security policies for Windows Mobile devices. It is designed as a desktop application that ships with a preset list of "security configurations". A security configuration can be thought of as a template, which contains a collection of individual policies and settings. For example, a security configuration could define policies such as whether unsigned applications are allowed to execute, whether RAPI is disabled etc. Using this tool, the developer can provision a Windows Mobile device with different configurations, and then test the application's behavior under these configurations. This tool can be used either on an emulator or an unlocked Windows Mobile device.
NQ Mobile Inc. ( NYSE:NQ) is a leading global provider of trusted mobile Internet services built on its world-class acquisition, engagement and monetization platform. The company was one of the first to recognize the growing security threats targeting smartphone users and now has about 242 million registered and 85 million active user accounts globally. NQ Mobile's cloud-based trust platform has been recognized by third-party testing facilities around the world as the most effective solution for detecting and combating mobile threats. NQ Mobile is recognized as a global pioneer in mobile innovation and technology leadership. NQ Mobile maintains dual headquarters in Dallas, TX, USA and Beijing, China.
Research in Motion Limited ( NasdaqGS:RIMM; TSX:RIM.TO) a global leader in wireless innovation, revolutionized the mobile industry with the introduction of the BlackBerry® solution in 1999. Today, BlackBerry products and services are used by millions of customers around the world to stay connected to the people and content that matter most throughout their day. Founded in 1984 and based in Waterloo, Ontario, RIM operates offices in North America, Europe, Asia Pacific and Latin America. Integral security features and an ever-expanding administrative toolset have earned BlackBerry® products the trust of some of the most secure organizations in the world. These security features have also made the BlackBerry solution a world leader in mobile security certifications.
Spare Backup, Inc. ( OTCBB:SPBU) is a leading provider of data backup and security software for smartphones, tablets and PCs. Spare Backup's software enables consumers and small to medium sized businesses to easily protect valuable computer and mobile data quickly, automatically and cost-effectively. Spare Backup software intelligently selects, secures and stores personal and business content on a continuous basis or according to the schedule of the user's choice. It also allows for the integration of that content across various devices and provides enhanced security features to protect valuable data on any lost or stolen devices. Spare Backup software is the first totally automated cloud-based backup service that is distributed on a stand-alone or private label basis through major retail and warranty service partners in North America and Europe.
Sybase, Inc (a division of SAP AG) ( NYSE: SAP) is the largest global enterprise software company exclusively focused on managing and mobilizing information from the data center to the point of action. Sybase provides open, cross-platform solutions that securely deliver information anytime, anywhere, enabling customers to create an information edge. The world's most critical data in commerce, communications, finance, government and healthcare runs on Sybase. Federal, state and local governments have reprioritized their IT initiatives to support emergency responders and defend against threats. Using Sybase solutions, agencies share data between sites, staff and each other-giving every stakeholder access to the real-time information they need to take appropriate action.
Mobile App Stocks
Arm Holdings plc (NasdaqGS:ARMH) designs the technology that is at the heart of advanced digital products, from wireless, networking and consumer entertainment solutions to imaging, automotive, security and storage devices. ARM's comprehensive product offering includes microprocessors, graphics processors, video engines, enabling software, cell libraries, embedded memories, high-speed connectivity products, peripherals and development tools. Combined with comprehensive design services, training, support and maintenance, and the company's broad Partner community, they provide a total system solution that offers a fast, reliable path to market for leading electronics companies.
Artificial Life, Inc. (OTC:ALIF) is a new kind of investor. We act as a global incubator and business network provider and facilitator for our investment companies, assisting them in their funding efforts, sales, production, and general business development activities. When needed, we also inject our valuable intellectual property into our investment companies for their use. We invest mainly in the BRICS ( Brazil, Russia, India, China and South Africa) markets with a focus on smartphone content and wireless technology such as: near field communication, mobile business apps and games, mobile health services, social networking apps and games, and mobile commerce. We have won many industry awards for outstanding technology and products in prior years.
Augme Technologies, Inc. (OTC:AUGT) provides strategic services and mobile marketing technology to leading consumer and healthcare brands. Selling its products and services under the Hipcricket brand, Augme's platform has provided measurable successes in over 225,000 campaigns for its clients, which include many of America's brand-name leaders (e.g., Macy's, MillerCoors and Clear Channel) in a variety of industries, along with their agencies. Augme's offerings allow marketers, brands, and agencies to plan, create, test, deploy, and track mobile marketing programs across every mobile channel, including SMS, MMS, 2D/QR codes, mobile websites, advertising networks, social media and branded apps. Augme's AD LIFE® platform facilitates consumer brand interaction and the ability to track and analyze campaign results. Using its own patented device-detection and proprietary mobile content adaptation software, AD LIFE® solves the mobile marketing industry problem of disparate operating systems, device types, and on-screen mobile content rendering. Augme also provides business-to-consumer solutions, including national mobile couponing campaigns, strategic mobile healthcare tools, custom mobile application development, and consumer data tracking and analytics. In addition to AD LIFE®, Augme in 2011 acquired the assets of Hipcricket, Inc. and JAGTAG, Inc. and licenses the digital broadcast platform BOOMBOX®. Augme is headquartered in New York City, with operations in Seattle, Atlanta, Dallas, Los Angeles, San Francisco, Chicago, Miami and Tucson.
Cirrus Logic Inc. (NasdaqGS:CRUS) develops high-precision, analog and mixed-signal integrated circuits for a broad range of innovative customers. Building on its diverse analog and signal-processing patent portfolio, Cirrus Logic delivers highly optimized products for a variety of audio and energy-related applications. With a focus on lowering system power, improving battery life and reducing board space, Cirrus Logic provides innovative ICs for smartphones and mobile applications. These solutions include smart audio codecs that are designed to off-load audio tasks from the applications processor, thereby saving system power, as well as Class D amplifiers that drive superior audio performance to the external speakers in space-saving, cost effective form factors.
Decision Diagnostics Corp. (OTC:DECN) is a leading developer of smart phone based remote Electronic Medical Record technologies. Decision Diagnostics Corp. is proud to feature MD@Hand and MD@Work-- smartphone-based medical communication network products. These products are geared to the medical insurance and pharmacy benefits management segments of the healthcare markets. Our smartphone-based medical communication network products provide physicians with critical patient information at the point of care; a handheld mobile device that allows physicians to carry, access, and update their patients' histories, medication data, and best care guidelines.
Glu Mobile, Inc. (NasdaqGS:GLUU) is a leading global developer and publisher of freemium games for smartphone and tablet devices. Glu is focused on creating compelling original IP games such as CONTRACT KILLER, GUN BROS, DEER HUNTER, BLOOD & GLORY, and SAMURAI VS. ZOMBIES DEFENSE on a wide range of platforms including iOS, Android, Windows Phone, Google Chrome, and MAC OS. Glu`s unique technology platform enables its titles to be accessible to a broad audience of consumers globally. Founded in 2001, Glu is headquartered in San Francisco with a major office outside Seattle, and international locations in Brazil, Canada, China, and Russia.
Mimvi, Inc. (OTC:MIMV) is a mobile search and recommendation technology company. Its proprietary search and "intelligent" recommendation algorithms enable the search and discovery of Mobile Apps, Mobile Content and Mobile Products across multiple devices and platforms, including: Apple's iPhone and iPad, Google Android, BlackBerry, Windows Phone, Facebook and Web Apps.
Mitek Systems Inc (NasdaqCM:MITK) is a mobile imaging software solutions provider that allows users to remotely deposit checks, pay their bills, get insurance quotes, and transfer credit card balances by snapping a picture with their camera-equipped smartphones and tablets instead of using the device keyboard. Mitek's technology increases convenience for the consumer by eliminating the need to go to the bank branch or automated teller machine, and dramatically reduces processing and customer acquisition costs while increasing customer retention. With a strong patent portfolio, Mitek is positioned as the leading innovator in mobile imaging software and currently provides its solutions to Fortune 500 financial services companies.
Nvidia Corp (NasdaqGS:NVDA) awakened the world to computer graphics when it invented the GPU in 1999. Today, its processors power a broad range of products from smartphones to supercomputers. NVIDIA's mobile processors are used in cell phones, tablets and auto infotainment systems. PC gamers rely on GPUs to enjoy spectacularly immersive worlds. Professionals use them to create 3D graphics and visual effects in movies and to design everything from golf clubs to jumbo jets. And researchers utilize GPUs to advance the frontiers of science with high performance computing. The company has more than 5,000 patents issued, allowed or filed, including ones covering ideas essential to modern computing.
RF Micro Devices, Inc (NasdaqGS:RFMD) is a global leader in the design and manufacture of high-performance radio frequency components and compound semiconductor technologies. RFMD's products enable worldwide mobility, provide enhanced connectivity and support advanced functionality in the mobile device, wireless infrastructure, wireless local area network (WLAN or WiFi), cable television (CATV)/broadband, Smart Energy/advanced metering infrastructure (AMI), and aerospace and defense markets. RFMD is recognized for its diverse portfolio of semiconductor technologies and RF systems expertise and is a preferred supplier to the world's leading mobile device, customer premises and communications equipment providers.
Sky-mobi Limited (NasdaqGM:MOBI) operates the leading mobile application store in China. Sky-mobi works with handset companies to pre-install its Maopao mobile application store on handsets and with content developers to provide users with high quality applications and content titles. Users of the Maopao store can browse, download and purchase a wide range of applications and content such as single-player games, mobile music and books. In addition, Sky-mobi has established a leading mobile social network community in China, the Maopao Community, where it offers popular localized mobile social games as well as applications and content with social network functions to its registered members. The Maopao store enables mobile applications and content to be downloaded and run on a variety of mobile handsets with different hardware and operating system configurations.
Skyworks Solutions, Inc. (NasdaqGS:SWKS) is an innovator of high performance analog semiconductors. Leveraging core technologies, Skyworks supports automotive, broadband, cellular infrastructure, energy management, GPS, industrial, medical, military, wireless networking, smartphone and tablet applications. The Company's portfolio includes amplifiers, attenuators, circulators, demodulators, detectors, diodes, directional couplers, front-end modules, hybrids, infrastructure RF subsystems, isolators, lighting and display solutions, mixers, modulators, optocouplers, optoisolators, phase shifters, PLLs/synthesizers/VCOs, power dividers/combiners, power management devices, receivers, switches and technical ceramics. Headquartered in Woburn, Mass., Skyworks is worldwide with engineering, manufacturing, sales and service facilities throughout Asia, Europe and North America.
Zagg Inc. (NasdaqGM:ZAGG) is a leading mobile device accessories and technology company with products that protect, personalize and enhance a consumer's mobile experience. ZAGG differentiates itself as the preferred brand by offering creative product solutions through targeted global distribution channels, with the broadest product offering in its sector. With a brand portfolio that includes ZAGG® and iFrogz™, the company manufactures and markets a complete line of products to improve the functionality of portable gadgets, including keyboards, cases, audio and protective films, through direct, retail, specialty and international channels.
More tech stocks are listed at the Investorideas.com directory including cloud computing and social networking stocks
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BC Residents and Investor Disclaimer : Effective September 15 2008 - all BC investors should review all OTC and Pink sheet listed companies for adherence in new disclosure filings and filing appropriate documents with Sedar. Read for more info: http://www.bcsc.bc.ca/release.aspx?id=6894
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Friday, December 07, 2012

Biotech Stock News; Aethlon Medical (OTCBB: AEMD) Note: A Medical Device Strategy to Address Metastatic Melanoma

SAN DIEGO - December 7, 2012 (Investorideas.com newswire) - Aethlon Medical, Inc. (OTCBB: AEMD), today released the following note authored by its Chairman and CEO, Jim Joyce.
At Aethlon Medical, our focus is to create revolutionary medical devices that save lives. In the treatment of Hepatitis C (HCV) infected individuals, we have demonstrated that our Hemopurifier® synergistically combines with drug therapy to accelerate the achievement of undetectable viral load. In cancer, I envision our opportunity to save lives will be driven by the discovery that our Hemopurifier® can addresses a therapeutic target that plays a pivotal role in cancer progression, yet remains beyond the reach of drug therapies. The target? Microvesicles known as exosomes, which are particles secreted by tumors underlying a wide-range of cancers.
Investorideas.com Newswire

When we first initiated our tumor-derived exosome research, it was based on a belief that these particles were immunosuppressive, much like glycoproteins that shed from HIV and other viral pathogens. However, the medical community consensus at the time was that exosomes had no biological function other than to discard cellular debris. Today, tumor-derived exosomes are known to suppress the immune response in cancer patients. Beyond possessing immunosuppressive properties, tumor-derived exosomes facilitate tumor growth, metastasis, and the development of drug resistance. Such deleterious effects underlie the pathogenesis of cancer, and as a result of our early research we have been able to obtain broad patent protection in the field. By addressing this unmet medical need, our objective is to deliver a medical device that improves the benefit of cancer therapies without adding drug resistance or interaction risks.
As more and more medical institutes establish exosome research programs, we benefit from new discoveries that will help us to understand which forms of cancer are most likely to benefit from our technology. In this regard, Dr. Annette Marleau (our Director of Tumor Immunology) provides the following review on recent discoveries that describe the implication of exosomes in metastatic melanoma, a form of cancer whose 5-year survival rate is less than 20%.
Exosomes As Therapeutic Targets In Metastatic Melanoma
Exosomes are nano-sized microvesicles released in large quantities by cancer cells that are key culprits in the pathogenesis of several cancer types. Exosomes are now recognized as biological delivery vehicles for communication between cells in almost every system of the body investigated to date. In the area of oncology, cancer derived exosomes are highly stable "packages" released from tumors that transport proteins and genetic material from their originating tumor cells to distant sites throughout the body to accelerate tumor progression. In melanoma patients, tumor-secreted exosomes serve as carriers of malignant proteins and their levels in circulation correlate with the aggressiveness of the cancer1. To date, cancer exosomes have been implicated in: a) immune suppression; b) enhancement of angiogenesis; and c) promotion of metastasis, which will be discussed below.
Owing to several recent publications that have defined their pathological roles in metastatic disease, melanoma exosomes are emerging as candidate therapeutic targets. Metastatic (stage 4) melanoma, the most aggressive form of skin cancer, has a five-year survival rate of only 15-20%2. This disease continues to be a challenge to treat, as the current standard treatments have proven to be ineffective and/or highly toxic. Since patients afflicted with metastatic melanoma have suppressed immune systems due to tumor- and drug-related effects, the efficacy of novel immunotherapeutic solutions is limited and only small percentages of patients experience durable responses and extended survival. Thus, the development of novel treatments to reliably bolster anti-cancer immune responses remains an urgent clinical objective.
Recent scientific studies have defined the importance of melanoma exosomes in the progression of cancer, thereby providing the rationale for targeting tumor-derived nano-vesicles therapeutically. In a 2012 publication in the prestigious journal Nature Medicine, Dr. David Lynden's group at Weill Cornell Medical College and their colleagues reported that melanoma tumors release exosomes that condition metastatic sites for growth of tumors and their supporting blood vessels3. This publication also identifies a correlation between high exosome concentrations in circulation with advanced disease and poor prognosis of patients. This knowledge reinforces the concept that a strategy for eliminating circulating exosomes could be beneficial for addressing metastatic disease.
A pivotal publication by Dr. Joshua Hood and colleagues at Washington University School of Medicine showed that melanoma exosomes migrate to lymph nodes and alter the biochemical milieu to allow lodging of cancer cells in the establishment of metastatic foci4. Once again, this study suggests that systemic clearance of melanoma exosomes could interrupt the "messenger system" underlying metastasis. Along these same lines, a study by Parolini and colleagues in The Journal of Biological Chemistry demonstrated that melanoma exosomes serve as delivery vehicles for spreading malignant proteins from high aggressive metastatic cells to less aggressive cancer cells5.This article raises the concept that exosomes from a primary tumor can transfer their cargo to distant organs, thereby allowing the malignancy to spread.
Experiments have also demonstrated that the functions of immune cells are impaired by melanoma exosomes6. Since the immune system is responsible for recognizing and destroying cancer cells, exosomes thereby manipulate immunity to allow tumors to grow unchecked. Additionally, since immunotherapy is administered to bolster the patient's endogenous immune response, melanoma exosomes impair the effectiveness of these treatments. On this basis, a device strategy for removal of circulating exosomes could be implemented to reverse immune dysfunction in order to improve the effectiveness of standard of care treatments against metastatic melanoma.
Given these recent scientific developments that reveal broad tumor growth promoting and immune inhibitory effects of melanoma exosomes, there is a strong impetus for moving forward with therapeutic targeting options, which do not exist to date. Clinical studies are needed to define the impact of exosomes in metastatic melanoma and to offer promising new treatment solutions that are urgently needed.
References
1 Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, Spada M, Perdicchio M, Marino ML, Federici C, Iessi E, Brambilla D, Venturi G, Lozupone F, Santinami M, Huber V, Maio M, Rivoltini L, Fais S. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One. 2009;4(4):e5219.
2 http://www.cancer.org/cancer/ skincancer-melanoma/detailedguide/ melanoma-skin-cancer -survival-rates
3 Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012 Jun;18(6):883-91.
4 Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 2011 Jun 1;71(11):3792-801.
5 Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, De Milito A, Coscia C, Iessi E, Logozzi M, Molinari A, Colone M, Tatti M, Sargiacomo M, Fais S. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem. 2009 Dec 4;284(49):34211-22.
6 Marton A, Vizler C, Kusz E, Temesfoi V, Szathmary Z, Nagy K, Szegletes Z, Varo G, Siklos L, Katona RL, Tubak V, Howard OM, Duda E, Minarovits J, Nagy K, Buzas K. Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro. ImmunolLett. 2012 Nov;148(1):34-8.
About Aethlon Medical
The Aethlon Medical mission is to create innovative medical devices that address unmet medical needs in cancer, infectious disease, and other life-threatening conditions. Our Aethlon ADAPT™ System is a revenue-stage technology platform that provides the basis for a new class of therapeutics that target the selective removal of disease enabling particles from the entire circulatory system. The Aethlon ADAPT™ product pipeline includes the Aethlon Hemopurifier® to address infectious disease and cancer; HER2osome™ to target HER2+ breast cancer, and a medical device being developed under a contract with DARPA that would reduce the incidence of sepsis in combat-injured soldiers and civilians. For more information, please visit www.aethlonmedical.com.
Certain statements herein may be forward-looking and involve risks and uncertainties. Such forward-looking statements involve assumptions, known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Aethlon Medical, Inc. to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such potential risks and uncertainties include, without limitation, that the company can successfully protect its intellectual property, that removal of exosomes from the human body will impact or lead to successful treatment of cancer, or that exosomes are the cause of tumor growth and progression, that the FDA will not approve the initiation of the Company's clinical programs or provide market clearance of the company's products, future human studies whether revenue or non-revenue generating of the Aethlon ADAPT™ system or the Aethlon Hemopurifier® as an adjunct therapy to improve patient responsiveness to established cancer or hepatitis C therapies or as a standalone cancer or hepatitis C therapy, the Company's ability to raise capital when needed, the Company's ability to complete the development of its planned products, the Company's ability to manufacture its products either internally or through outside companies and provide its services, the impact of government regulations, patent protection on the Company's proprietary technology, product liability exposure, uncertainty of market acceptance, competition, technological change, and other risk factors. In such instances, actual results could differ materially as a result of a variety of factors, including the risks associated with the effect of changing economic conditions and other risk factors detailed in the Company's Securities and Exchange Commission filings. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.
Contacts:
James A. Joyce
Chairman and CEO
858.459.7800 x301
jj@aethlonmedical.com
Jim Frakes
Chief Financial Officer
858.459.7800 x300
jfrakes@aethlonmedical.com
Marc Robins
877.276.2467
mr@aethlonmedical.com
Published at Investorideas.com Newswire
More info on AEMD at Investorideas.com Visit: http://www.investorideas.com/CO/AEMD/
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Thursday, December 06, 2012

Automotive Stock Alert; MWW Automotive (OTCQB: MWWC) Gains 110% in Morning Trading

Point Roberts, WA - December 6, 2012 (Investorideas.com newswire) Investorideas.com staff: Investorideas.com, an investor research portal specializing in sector research for independent investors, including automotive stocks, issues a trading alert for MWW Automotive Group (OTCQB: MWWC). The stock is trading at $0.0011, up 0.0006 or 120.00% as of 11:01AM EST on just under 4 Million shares.

The Company recently reported an agreement with G.S.I selecting MWW as its North American Finishing Supplier for their industrial product offerings in North America with multiple year painting and fulfillment programs for Industrial and Agricultural Equipment components.
G.S.I. is a global Tier One supplier of complete turnkey products and systems for the global automotive and industrial markets, based in Chicago. G.S.I. primary markets include agricultural, construction, automotive and electrical equipment and machinery. Major clients include, among others, AGCO, Argo Tractors, Carraro, Case New Holland, Caterpillar, Class, Massey Ferguson and Shanghai New Holland.
Full news: http://www.investorideas.com/CO/MWWA/news/2012/11291.asp
Investorideas.com Newswire About MWW Automotive Group (OTCQB: MWWC)
The MWW Automotive Group (MWWC) is headquartered in Howell, Michigan, with a "Class A" manufacturing and logistics facility in Baroda, Michigan for the production of high quality OE automotive and industrial products. MWW delivers its products and "Class A" painting, assembly and logistics services directly to major US and Foreign automobile manufacturers' Vehicle Processing Centers (VPC) and/or assembly lines in North America. MWW's industrial products are delivered directly to the industrial manufacturers for installation in their facilities. MWW provides substantial added value to the sale of vehicles and industrial products for leading international automobile and industrial manufacturers such as Toyota, BMW, Chevrolet, Hyundai, Kia Motors, MAZDA, GM, Ford, and their strategic partners ROUSH Performance and Polytec.
For more information please visit www.mwwautomotive.com
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Agriculture Stocks: The Global Growth for Stevia; Sunwin Stevia's (OTCQB:SUWN) Distribution Partner WILD Flavors Sees Positive Results One Year After the EU Grants Approval

POINT ROBERTS, WA - December 6, 2012 (Investorideas.com Newswire) Investorideas.com, an investor research portal specializing in sector research for independent investors, issues a snapshot for the global stevia market and stocks within the sector, including Sunwin Stevia International, Inc. (OTCQB:SUWN).

Recently President of the International Stevia Council (ISC) said Stevia had fundamentally changed the sweetener market. Lauren Bandy, Ingredients Research Analyst with Euromonitor International told Investorideas.com, "There is no doubt that stevia has shaken the high intensity sweeteners market, most of all because it is sourced naturally. This puts it at a great advantage to other high intensity sweeteners such as aspartame and sucralose, which are chemically derived. It still is relatively expensive compared to other sweeteners such as sugar, and only represents 2% of the high intensity sweeteners market in volume terms in 2012, although this has doubled since 2011."
She went on to note, "I think stevia manufacturers will continue to target large, multinational brands, as they are at the moment. Stevia offers food and beverage manufacturers a way to reduce the sugar content of their products in a more natural way. Health and wellness is a key trend in the food and beverage sector and stevia is perfectly positioned to capitalize on the growth of the better-for-you market."
According to Foodingredientsfirst.com, "One year after the European Union granted approval for steviolglycosides to be marketed, WILD Flavors ( Sunwin Stevia's (OTCQB:SUWN) distribution partner) has noted positive interim results. The great-taste expert has worked with customers to create a number of stevia-sweetened products that have been market successes — everything from beverages to candies."
Sunwin (OTCQB:SUWN) began an expansion production project in April 2012 in anticipation of an improvement in demand in the coming years as the use of stevia as a healthy low calorie sweetener continues to increase across the globe. Sunwin has begun trial production of its new lines and anticipates its added production capabilities to be fully operational in the first quarter of calendar 2013.
Lauren Bandy reports " Western Europe is the world's largest packaged food market in value terms and was worth just under US$600 billion in 2012. Since its EU approval, stevia suppliers have really been tapping into this lucrative market. Euromonitor shows that stevia consumption in Western Europe in volume terms is forecast to grow by 50% over 2012-2016, from 190 tonnes in 2012 to nearly 300 tonnes in 2016.
A number of key brands have since launched stevia containing products in Europe - for example in France and Ireland, the Coca Cola Company has reformulated Sprite using stevia, reducing sugar content by 30%."
Health Canada just gave stevia the okay to become an ingredient in mainstream food and beverages. PureCircle Limited (LSE:PURE.L) one of the world's leading producer of high purity stevia ingredients for the global food and beverage industry and GLG Life Tech (GLGLF) say they have been ramping up for the anticipated Canadian approval according to a recent article in foodnavigator-usa.com.
In terms of potential obstacles Lauren Bandy said there are a few to overcome. " India is the most significant market and the last of the BRIC countries not to permit stevia as a sweetening ingredient. Countries in Latin America and Asia Pacific - which also have the fastest growing packaged food and soft drink markets globally - have been using stevia for many years.
The other hurdle to stevia's global success is the controversy surrounding its natural status, a debate which is stronger in Europe than America. Because stevia has an E number (E960) and because steviol glycosides - the sweet compounds - have to be extracted from the plant and processed, some consumers consider stevia as ‘just another additive'.
Stevia's bitter aftertaste also remains an obstacle, although this is a highly researched and rapidly developing area and is unlikely to affect its market penetration; Euromonitor forecast that stevia will have an annual growth rate of 23% globally over 2011-2016, in volume terms."
To address any concerns with taste, WILD's Sunwin Stevia™ (OTCQB:SUWN) brand provides beverage manufacturers one-source solutions: high-quality Stevia extracts in varying Reb Alevels plus WILD's natural Taste Optimization Technology.
The natural Taste Optimization Technology eliminates the characteristic licorice nuance and partly bitter aftertaste of Stevia. Manufacturers can therefore create delicious tasting, naturally sweetened products with the natural sweetening system Stevia, ranging from near waters, tea drinks or carbonated soft drinks, to fruit juice-containing drinks and beer mixes. WILD's Sunwin Stevia™ allows for great-tasting calorie-reduced, low calorie or calorie-free varieties, according to customer demands and market requirements.
About WILD Flavors GmbH,
WILD Flavors GmbH, based in Zug, Switzerland, is one of the world's leading privately-owned manufacturers of natural ingredients for the food and beverage industry. WILD Flavors provides specific flavors, colors, and ingredients as well as innovative and great tasting concepts through application expertise and technological advancements. www.wildflavors.com or www.wild.de
About Sunwin Stevia International, Inc. (OTCQB: SUWN)
Sunwin Stevia International, Inc. engages in the areas of zero calorie, all natural sweeteners (Sunwin Stevia™ Extracts). As an industry leader in agricultural processing, Sunwin has built an integrated global firm with the sourcing and production capabilities to meet the needs of consumers throughout the world. For more info about Sunwin, please visit http://www.sunwininternational.com
Contact:
SUWN contact: Dore Perler
U.S. Representative
954-232-5363
ir@sunwininternational.com
Lauren Bandy works as Ingredients Research Analyst with Euromonitor International. She directly contributes to the content and quality of Euromonitor International's Food & Drinks Ingredients research, with a special focus on health ingredients, sweeteners, and cocoa ingredients. Lauren monitors key industry trends and forecasts and is responsible for the writing of articles and analysis, which provide detailed insight into the state of the industry. In her current role at Euromonitor International, Lauren uses her expert knowledge of the ingredients industry to create quality data and insight on a range of topics including key market trends and opportunities, regulation and innovative ingredients.
Lauren holds a degree in Nutrition from King's College, London.
Investorideas.com Newswire Research more Agriculture and stevia stocks at Investorideas.com
http://www.investorideas.com/MSS/Arg_Stock_List.asp
Article source: http://www.foodingredientsfirst.com/news/Wild-Sees-Positive-Interim-Results-One-Year-After-Stevia-Approval.html
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Wednesday, December 05, 2012

Investorideas.com; helping public companies stay out of the red and investors see a little green for Holidays!

Point Roberts, WA - December 5, 2012 (www.investorideas.com newswire) Investorideas.com, an investor research portal specializing in sector research for independent investors issues a holiday special limited offer for publicly traded companies on and investors trading the TSX, OTC, NASDAQ and ASX markets.

While everyone is focused on the worry of the fiscal cliff, Investorideas.com is spreading some holiday cheer to public companies and investors in anticipation that a deal is agreed upon and markets can rebound into the New Year.
The limited time holiday offer from www.Investorideas.com makes stocks stand out within their sector with a company profile summarizing all the key investor information plus unlimited news releases published on the Investor Ideas newswire. This also includes its syndication network of news sites, investor sites and social media. The annual cost on a limited time offer has been reduced to just under $10,000 as a one time fee!
Investorideas.com has also adjusted its investor membership program to include monthly memberships for just $12.99 per month, discounted from its previous $27 month fee. Investor Ideas members get access to fourteen stock directories with 24/7 login. Sectors include energy stocks, biotech, water and renewable energy stocks.
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