Tuesday, November 03, 2020

Investor Ideas #Potcasts, #Cannabis News and #Stocks on the Move; Episode 490 (TSX: $DN.TO) (OTCQX: $VRNDF) (NASDAQ: $GWPH) (NASDAQ: $VFF) (TSX: $VFF.TO)

Investor Ideas #Potcasts, #Cannabis News and #Stocks on the Move; Episode 490 (TSX: $DN.TO) (OTCQX: $VRNDF) (NASDAQ: $GWPH) (NASDAQ: $VFF) (TSX: $VFF.TO)

Today's podcast sponsored by Cannabis Suisse Corp. (OTC: $CSUI), a fully licensed cannabis cultivation and distribution company in Switzerland

 


Delta, Kelowna, BC, November 3, 2020 (Investorideas.com Newswire) www.Investorideas.com, a global news source covering leading sectors including marijuana and hemp stocks and its potcast site, www.potcasts.ca  release today’s podcast edition of  cannabis news and stocks to watch plus insight from thought leaders and experts.

 

Listen to the podcast:

https://www.investorideas.com/Audio/Podcasts/2020/110320-StocksToWatch.mp3

 

Read this in full at https://www.investorideas.com/news/2020/cannabis-potcasts/11031DN-VRNDF-GWPH-VFF.asp

 

Hear Investor ideas cannabis potcast on iTunes  

 

Today’s podcast overview/transcript:

 

Good afternoon and welcome to another episode of Investorideas.com "Potcast" featuring cannabis news, stocks to watch as well as insights from thought leaders and experts.

 

Today’s podcast is sponsored by Cannabis Suisse Corp. (OTC: CSUI ), a fully licensed cannabis cultivation and distribution company in Switzerland, for recreational tobacco products and medical CBD oils. The Company's facilities for producing cannabis are based in Dietikon, Switzerland, and contain the art surveillance equipment to enable an around the clock webcast. Cannabis Suisse grows high quality, organic cannabis with sustainable, all-natural principles. The Company's products are laboratory tested to ensure the end users have access to a standardized, safe and consistent product. Cannabis Suisse proprietary trademarked MoldStandard is a quantitative microbiology method for analyzing yeast and mold counts in harvested cannabis plants. Cannabis Suisse proprietary trademarked CannaMec is a method for quantifying and removing residual solvents during packaging and storage of CBD products. Cannabis Suisse Corp. currently sells via a distribution network of Swiss retailers and online shops, under the retail brand Alpine Cannabis.

 

In today’s podcast we look at a few public and private company announcements.

Pure Extracts Technologies Corp., a plant-based extraction company focused on cannabis, hemp, and functional mushroom sectors, announced that the company’s stock will commence trading on the Canadian Securities Exchange (“CSE”) under the symbol “PULL” on November 5, 2020.

 

“There currently is a tremendous consumer demand for natural health products with the ability to immediately enhance our quality of life. With Health Canada officially granting Pure Extracts a Standard Processing License under the Cannabis Act, this has put us on a path to deliver full-spectrum oil products by the end of Q4, 2020” said chief executive officer Ben Nikolaevsky. “Our trading debut on the CSE is another vote of confidence in our ability to effectively meet the needs of consumers focused on receiving cannabis, hemp and functional mushroom products.”

 

Pure Extracts would like to thank its expert tradespeople who worked tirelessly on the its state-of-the-art facility in Pemberton, BC, its team of dedicated employees, and the investors who have financed the company for a total $9.45MM CAD allowing it to become a world-class, plant-based extraction company.

 

Pure Extracts was incorporated under the BCBCA and has its offices and operations in Pemberton, British Columbia. On September 25, 2020, Pure Extracts was granted its Standard Processing License by Health Canada under the Cannabis Act. Pure Extracts is undertaking the operations of toll processing, white labelling, and developing its own private label of products incorporating its full spectrum THC and CBD based extracted oils.

 

Additionally, Pure Extracts is presently expanding its business to include functional mushrooms extraction by working on functional mushroom extraction processes compatible with its existing infrastructure. Pure Extracts has a fully built CO2 extraction facility built to European Union GMP standards and intends to seek EU GMP certification of its operations allowing it to export its products for sale in Europe where such products are legal.

 

DELTA 9 CANNABIS INC. (TSX: DN) (OTCQX: VRNDFannounced that it has now surpassed one million transactions through its retail cannabis stores since legalization of recreational cannabis use. The Company opened its first “Delta 9 Cannabis Store” on October 17, 2018 and has since grown its retail store footprint to seven operating stores in the Manitoba and Alberta markets.

 

In addition to achieving the milestone number of transactions, the Company is pleased to provide the following statistics in connection with its retail cannabis business;

      Over 1,000,000 in-store and online transactions

      Over $50 Million in-store and online retail revenues

      Average transaction size of $50.20 per transaction

      Over 1.5 Million unique website visitors to delta9.ca

      Over 17,000 square feet of retail store space averaging $2,021 in revenue per square foot per year.

      Average Gross Profit margin of approximately 26%

 

"We are very pleased with the revenue growth generated from our retail stores since legalization in 2018," said John Arbuthnot, CEO of Delta 9. “Delta 9 has stayed focused on its strategy to vertically integrate into the retail segment and leveraging its retail business as a means to facilitate distribution of Delta 9 branded products directly to Canadian consumers.”

Management believes that there are a number of benefits to pursuing a vertical integration strategy into retail sales including:

      Control over a direct to consumer sales force and product distribution;

      Control over direct to consumer branding and marketing initiatives;

      Capturing additional revenues and gross margin from retail sales; and

      Direct feedback from consumers regarding product trends, marketing strategies, etc.

 

GW Pharmaceuticals plc (NASDAQ: GWPH), a world leader in the science, development, and commercialization of cannabinoid prescription medicines, along with U.S. subsidiary Greenwich Biosciences, today announced that the Company has initiated the first U.S. Phase 3 clinical trial studying nabiximols for multiple sclerosis (MS)-associated spasticity.

 

Nabiximols, known as Sativex® outside of the U.S. and approved for use to treat MS spasticity in over 25 countries, is a complex botanical medicine formulated from extracts of the cannabis plant administered as an oral spray. Positive results from three previous European Phase 3 clinical studies show nabiximols was well-tolerated and provided continued reductions in patient-reported spasticity for individuals with MS.

 

This Phase 3 trial is one of five pivotal studies planned for nabiximols in MS spasticity, with the remaining studies on track to commence either later this year or in 2021. GW expects that a positive result in any one of these five studies will enable an NDA submission, potentially as early as mid- next year.

 

“We are excited that the U.S. Phase 3 clinical program evaluating nabiximols in Multiple Sclerosis spasticity is now recruiting patients, after a delay due to COVID-19. Given the rigorous studies already conducted on the medicine outside of the U.S., and positive discussions with the FDA, we believe that we have a clear path to an NDA submission, potentially as soon as next year, and a significant second product opportunity for GW in the U.S.,” stated Justin Gover, GW’s Chief Executive Officer. “Now is the ideal time to develop nabiximols in the U.S. as research shows a significant percentage of spasticity patients are today self-medicating using unapproved cannabis products to relieve their spasticity.”

 

“There is a significant need for new treatments to address spasticity in MS patients, a challenging condition with little therapeutic innovation in decades in the United States,” said Dr. Stephen Krieger, Associate Professor of Neurology at the Mount Sinai Hospital.

 

“Nabiximols has the potential to be a rigorously tested and FDA-regulated cannabis-derived medicine for people living with MS. I look forward to participating as an investigator in this study which will evaluate the effect of nabiximols on the frequency of muscle spasms.”

 

The study is a Phase 3, double-blind, parallel, placebo-controlled study that will evaluate the safety and efficacy of nabiximols for spasm frequency over a 12-week period and is expected to enroll 446 participants.  The first patient is now screened and in baseline evaluation.

 

Beyond this initial study, the Company intends to commence the following additional Phase 3 trials of nabiximols for MS-associated spasticity:

      Phase 3 muscle tone studies – placebo-controlled cross-over design

      N=52; Expected start: Q4 2020 (subject to COVID)

      N=190; Expected start: Q1 2021

      N=36 (nabiximols responders); Expected start: Q1 2021

      Phase 3 spasm frequency studies – placebo-controlled parallel group

      N=~200 (nabiximols responders); Expected start: Q2 2021

 

Village Farms International, Inc. (NASDAQ: VFF) (TSX: VFFannounced it has completed the acquisition from Emerald Health Therapeutics, Inc. of 36,958,500 common shares of Pure Sunfarms Corp. owned by Emerald, representing approximately 41.3% of the issued and outstanding common shares of Pure Sunfarms. With the completion of the Pure Sunfarms Transaction, Village Farms now owns 100% of the common shares of Pure Sunfarms. The acquisition of the Pure Sunfarms shares will be immediately accretive to Village Farms' net income.

 

"Village Farms conceived of a joint venture to launch its Canadian cannabis business, and the result, Pure Sunfarms, is now one of the leading Canadian cannabis companies. With this transaction our shareholders will now fully benefit from our initiative," said Michael DeGiglio, CEO, Village Farms. "Pure Sunfarms is well positioned for long-term growth as one of what we believe will be just a small number of major suppliers to the Canadian cannabis market. Importantly, as part of the Village Farms organization Pure Sunfarms can now pursue additional opportunities to further leverage its success to date and increase its earnings potential. I am pleased to welcome the outstanding management team and employees of Pure Sunfarms to our organization, and welcome back so many Village Farms' personnel who transitioned to our cannabis venture in the early days to ensure that Pure Sunfarms would benefit fully from Village Farms' decades of experience and site-specific operational expertise. Pure Sunfarms' CEO, Mandesh Dosanjh, and his entire team have done exceptional work in bringing Village Farms' vision to reality, and we look forward to their continued contribution to its success as part of Village Farms going forward."

 

"The acquisition of the entirety of Pure Sunfarms is a defining moment for Village Farms, furthering our transformation to a vertically integrated, plant-based consumer packaged goods company. It allows us to fully leverage the invaluable cannabis expertise Village Farms has gained in combination with the organizational strength underlying the Village Farms produce business to pursue high-growth opportunities in emerging legal cannabis and CBD markets in the United States and targeted markets internationally. We will do so with the same thoughtfulness, prudence, strategic decision making and focus on near-term profitability and long-term return on invested capital that has been fundamental to the success of our investment in Pure Sunfarms."

 

"We especially look forward to the potential for U.S. regulatory changes that would permit us to pursue our U.S. cannabis aspirations. With one of the largest greenhouse footprints in the U.S., located in one of the best regions for growing in the country, alongside our cannabis success in Canada, we believe there is no company better positioned for long-term success in the U.S. cannabis industry. We are ready to move quickly and aggressively as soon as the regulatory environment permits."

 

Upon closing of the Pure Sunfarms Transaction, Pure Sunfarms will be fully consolidated in Village Farms' financial results. Village Farms will report its third quarter financial results and the third quarter financial results of Pure Sunfarms on November 13, 2020. Village Farms' financial results for the three and nine months ended September 30, 2020 will continue to reflect Village Farms' 58.7% ownership of Pure Sunfarms as an investment in a joint venture.

 


Once again, today’s podcast is sponsored by Cannabis Suisse Corp. (OTC: CSUI ), a fully licensed cannabis cultivation and distribution company in Switzerland, for recreational tobacco products and medical CBD oils. The Company's products are laboratory tested to ensure the end users have access to a standardized, safe and consistent product. Cannabis Suisse Corp. currently sells via a distribution network of Swiss retailers and online shops, under the retail brand Alpine Cannabis.

 

Investor ideas reminds all listeners to read our disclaimers and disclosures on the Investorideas.com website and that this podcast is not an endorsement to buy products or services or securities. Investors are reminded all investment involves risk and possible loss of investment.

 

Learn more about our cannabis podcasts at https://www.investorideas.com/Audio/Potcasts.asp

Or www.potcasts.ca

 

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Potcasts is now a certified word mark Trademark on the blockchain through Cognate, Inc. CM Certification-Registration Number: 10468217708

About Investorideas.com - News that Inspires Big Investing Ideas

Investorideas.com is a recognized news source publishing third party news, research and original financial content. Learn about investing in stocks and sector trends with our news alerts, articles, podcasts and videos, looking at cannabis, crypto, AI and IoT, mining, sports biotech, water, renewable energy and more. Investor Idea’s original branded content includes the following podcasts and columns : Crypto Corner , Play by Play sports and stock news column, Investor Ideas Potcasts Cannabis News and Stocks on the Move podcast and column,  Cleantech and Climate Change , Exploring Mining  the AI Eye .

Disclaimer/Disclosure: Investorideas.com is a digital publisher of third party sourced news, articles and equity research as well as creates original content, including video, interviews and articles. Original content created by investorideas is protected by copyright laws other than syndication rights. Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investing involves risk and possible losses. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. Contact management and IR of each company directly regarding specific questions. Disclosure: Cannabis Suisse Corp. (OTC: CSUI),is a paid featured company on Investorideas.com More disclaimer info: https://www.investorideas.com/About/Disclaimer.asp Learn more about publishing your news release and our other news services on the Investorideas.com newswire https://www.investorideas.com/News-Upload/ and tickertagstocknews.com

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#AIEye #Podcast Episode 467: Wipro (NYSE: $WIT) and AWS (NasdaqGS: $AMZN) Launch Wipro AWS Business Group, and ImmunoPrecise (TSXV: $IPA.V) Collaborates with #AI Research Institute Mila

#AIEye #Podcast Episode 467: Wipro (NYSE: $WIT) and AWS (NasdaqGS: $AMZNLaunch Wipro AWS Business Group, and ImmunoPrecise (TSXV: $IPA.V) Collaborates with #AI Research Institute Mila

 

Global Mobile AI Market to Reach $17.79 Billion by 2025

 


Point Roberts WA, Vancouver BC – November 3, 2020  – Investorideas.com (www.investorideas.com), a global investor news source covering Artificial Intelligence (AI) brings you today’s edition of  The AI Eye-  watching stock news, deal tracker and advancements in artificial intelligence.

 

Listen to today’s podcast:

https://www.investorideas.com/Audio/Podcasts/2020/110320-AI-Eye.mp3

 

Read this in full at https://www.investorideas.com/news/2020/artificial-intelligence/11031AIEye-WIT-AWS-ImmunoPrecise.asp

 

Hear the Ai Eye on Spotify  

 

Today’s Column- The AI Eye- Watching stock news, deal tracker and advancements in artificial intelligence

 

Stocks discussed: (NYSE:WIT) (TSXV:IPA)

 

Wipro Limited (NYSE:WIT) and Amazon Web Service (AWS), a subsidiary of Amazon (NasdaqGS:AMZN), announced the launch of Wipro AWS Business Group (WABG), described as “a unit designed to help customers fast-track their cloud transformation journey on AWS.” WABG brings together Wipro’s services and experience with AWS’s cloud platforms to “drive business acceleration.” Matt Garman, Vice President, Sales and Marketing, AWS, said:

 

"By establishing the Wipro AWS Business Group, we are taking an important step forward in the long-standing relationship between the two companies. This business group will empower clients to rapidly achieve the benefits of moving to AWS, eliminate the undifferentiated heavy lifting of managing their IT infrastructure, and instead focus on their core business."

 

ImmunoPrecise Antibodies Ltd. (TSXV:IPAannounced a research partnership with AI research institute Mila. The collaboration will leverage data and artificial intelligence to research and develop talent initiatives to advance next generation innovation in therapeutics. Yoshua Bengio, the founder of Mila, said:

 

"This partnership opens up an exciting opportunity for AI to tap into unexplored datasets generated by ImmunoPrecise's effective and high-throughput therapeutic antibody discovery platforms, to contribute to the design of new therapeutics against life-threatening diseases that challenge humanity.”

 

Jennifer Bath, CEO of ImmunoPrecise, said:

 

"This partnership reflects IPA's deep-seeded commitment to innovation. Combining our efforts with the world-renowned talent at Mila catalyzes our advancements beyond the traditional life science model, as we continue to embrace the future of therapeutic discovery to accelerate the commercialization of life saving therapeutics."

 

Global Mobile AI Market to Reach $17.79 Billion by 2025

 

A report published by Data Bridge Market Research finds that the global Mobile Artificial Intelligence (AI) market will grow from $5.14 billion in 2017 to $17.79 billion by 2025 with a compound annual growth rate (CAGR) of 28.43 percent in the forecast period 2018-2025. The report’s description identifies “increasing demand in the field of drones, robotics, and surveillance cameras”, “growing demand for edge computing in IoT,” and a “rising focus on low cost AI-capable processors and cognitive computing,” as drivers in the market, but highlights the rapid replacement of new technology and the expense of maintaining technology as potential restraints to growth.

 

Sam Mowers, Investorideas.com

 

Read and hear other editions of the AI  Eye

 

For a list of artificial intelligence stocks on Investorideas.com visit here

Investors can trade these stocks and other ideas on our site using our  list of top stock trading apps including Robinhood , Acorn, Stash  and others.

 

About Investorideas.com - News that Inspires Big Investing Ideas Investorideas.com is a recognized news source publishing third party news, research and original financial content. Learn about investing in stocks and sector trends with our news alerts, articles, podcasts and videos, looking at cannabis, crypto, AI and IoT, mining, sports biotech, water, renewable energy and more. Investor Idea’s original branded content includes the following podcasts and columns : Crypto Corner , Play by Play sports and stock news column, Investor Ideas Potcasts Cannabis News and Stocks on the Move podcast and column,  Cleantech and Climate Change , Exploring Mining  the AI Eye .

The Investorideas.com podcasts are also available on iTunes,  Spotify, Tunein, Stitcher, Spreaker.com, iHeartRadio and Google Play Music.

 

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Disclaimer/Disclosure: Investorideas.com is a digital publisher of third party sourced news, articles and equity research as well as creates original content, including video, interviews and articles. Original content created by investorideas is protected by copyright laws other than syndication rights. Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investing involves risk and possible losses. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. Contact management and IR of each company directly regarding specific questions. More disclaimer info: https://www.investorideas.com/About/Disclaimer.asp Learn more about publishing your news release and our other news services on the Investorideas.com newswire https://www.investorideas.com/News-Upload/ and tickertagstocknews.com  Global investors must adhere to regulations of each country. Please read Investorideas.com privacy policy: https://www.investorideas.com/About/Private_Policy.asp

 

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#ExploringMining #Podcast Episode 115 – #Mining #Stocks News from (NYSEAmerican: $GORO) (TSXV: $MAE.V) (TSXV: $CQR.V) (TSXV: $GZD.V)

#ExploringMining #Podcast Episode 115 – #Mining #Stocks News from (NYSEAmerican: $GORO) (TSXV: $MAE.V) (TSXV: $CQR.V) (TSXV: $GZD.V)

 


Point Roberts WA, Delta BC, November 3, 2020 Investorideas.com, a global investor news source covering mining and metals stocks releases today’s edition of Exploring Mining Podcast, featuring stock news from TSX, TSXV ,CSE, ASX, NASDAQ, NYSE  companies plus interviews with CEO's and leading experts.

 

Listen to the podcast:

https://www.investorideas.com/Audio/Podcasts/2020/110320-Mining.mp3

 

Read this in full at https://www.investorideas.com/news/2020/exploring-mining/11031GORO-MAE-CQR-GZD.asp

 

Listen to Exploring Mining podcast on iTunes Apple podcasts   

 

Listen to Exploring Mining on Spotify

 

Gold Resource Corporation (NYSEAmerican:GORO) has reported consolidated production results for its third quarter ended September 30, 2020, including production of 12,575 gold ounces and 333,761 silver ounces. This quarter also saw the company report a net income of $5.0 million or $0.07 per share. Gold Resource Corporation’s CEO and President, Jason Reid, said:

 

“Our successful third quarter demonstrates our strength and determination. Despite the mandatory two-month shutdown in Mexico during the second quarter, our Oaxaca Mining unit is back to generating free cashflow while putting employee and community health and safety first. Nevada also delivered on generating free cash flow with its record quarterly gold production, a 51% increase over the prior quarter, while continuing rigorous COVID protocols. Additionally, we made a deliberate strategic move to unlock and increase shareholder value from both mining units by initiating the spin-off of the Nevada Mining Unit to shareholders as Fortitude Gold Corporation.”

 

Maritime Resources Corp. (TSXV:MAE) has announced additional assay results from its ongoing exploration program at the Hammerdown Gold Project in Newfoundland and Labrador. Garett Macdonald, President and CEO of Maritime Resources, explained::

 

“Over the past few weeks our exploration program has begun branching out from our main Hammerdown gold deposit to test key targets along the 5 kilometre SW-NE geological trend to identify new sources of mineralization that could add value to Hammerdown Gold Project.

 

At the Orion deposit, located 1.5 kilometres SW of Hammerdown, recent drilling continues to define a wide zone of shallow mineralization amenable to open pit mining and a potentially new style of structurally controlled, high grade mineralization containing visible gold. We intend to follow up on these intersections with step out drilling to further evaluate these opportunities."

 

Conquest Resources Limited (TSXV:CQR) has expanded its land holdings in the Temagami Mining Camp near Sudbury in Northern Ontario, Canada, after the staking of 588 mining cells, encompassing approximately 93 sq km. According to the press release, the company “now controls over 220 sq km of underexplored territory, including the past producing Golden Rose Mine at Emerald Lake,” in the aforementioned Temagami Mining Camp

 

Grizzly Discoveries Inc. (TSXV:GZD) has closed a private placement, earning it gross proceeds of $230,300. According to the press release, the company “intends to use the proceeds from the Units for general working capital, and the proceeds from the Units and FT Units on exploration of its Greenwood and Robocop mineral projects in British Columbia.”

 

Investors can trade these stocks and other ideas on our site using our  list of top stock trading apps including Robinhood , Acorn, Stash  and others.

 

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Research mining stocks at Investorideas.com with our mining stocks directory at Investorideas.com https://www.investorideas.com/Gold_Stocks/Stocks_List.asp 

 

About Investorideas.com - News that Inspires Big Investing Ideas Investorideas.com is a recognized news source publishing third party news, research and original financial content. Learn about investing in stocks and sector trends with our news alerts, articles, podcasts and videos, looking at cannabis, crypto, AI and IoT, mining, sports biotech, water, renewable energy and more. Investor Idea’s original branded content includes the following podcasts and columns : Crypto Corner , Play by Play sports and stock news column, Investor Ideas Potcasts Cannabis News and Stocks on the Move podcast and column,  Cleantech and Climate Change , Exploring Mining  the AI Eye .

 

Disclaimer/Disclosure: Investorideas.com is a digital publisher of third party sourced news, articles and equity research as well as creates original content, including video, interviews and articles. Original content created by investorideas is protected by copyright laws other than syndication rights. Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investing involves risk and possible losses. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. Contact management and IR of each company directly regarding specific questions.

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#Covid19 /#Cytokine Storm Syndrome Alert - Sigyn Therapeutics (OTC: $SIGY) CEO Note Discusses Sigyn Therapy™ to address a significant unmet need in global health; @Sigyn_inc

#Covid19 /#Cytokine Storm Syndrome Alert - Sigyn Therapeutics (OTC: $SIGY) CEO Note Discusses Sigyn Therapy™ to address a significant unmet need in global health; @Sigyn_inc

 

SAN DIEGO, November 3, 2020 / Investorideas.com Newswire – Therapeutic technology stock news - Sigyn Therapeutics, Inc. (OTCMarkets: SIGY), today released the following note authored by its Chairman and CEO, Jim Joyce.

                                            

Read this news, featuring SIGY in full at https://www.investorideas.com/news/2020/biotech/11031Sigyn-Therapeutics.asp

 

Dear Current and Candidate Shareholders,

 

We created Sigyn Therapy™ to address a significant unmet need in global health; the treatment of life-threatening inflammatory conditions that are precipitated by Cytokine Storm Syndrome (The Cytokine Storm). The intent of this communication (the first in a series) is to introduce and familiarize you with our technology and therapeutic opportunities, which include large market indications that remain beyond the reach of drug therapies.

 

Cytokine storm syndrome is characterized as a dysregulated response of the immune system, which can be induced by a wide-range of infectious and non-infectious conditions. Since the outset of the current pandemic, medical journals have widely reported cytokine storm syndrome to be a leading cause of death resulting from severe COVID-19 infections.  A hallmark of the cytokine storm is an excessive or uncontrolled release of pro-inflammatory cytokines, which can induce multiple organ failure and result in death.

 

To recalibrate this dysregulated immune response, we designed Sigyn Therapy to deplete a broad-spectrum of inflammatory contributors from the bloodstream. The most prevalent condition associated with cytokine storm syndrome is sepsis.  Earlier this year, the Journal Lancet reported that sepsis kills more people around the world than all forms of cancer combined.  The Lancet reported that in 2017, there were 48.9 million cases of sepsis and 11 million deaths.  In that same year, the journal reported an estimated 20.3 million sepsis cases and 2.9 million deaths were among children younger than 5 years old.  In the United States, sepsis was reported to be the most common cause of in-hospital deaths and accounted for more than $24 billion in annual costs.

 

To date, more than 70 controlled human studies have been conducted to evaluate the safety and benefit of candidate drugs to treat sepsis. With one brief exception (Xigris from Eli Lilly), none of these studies resulted in an approved drug therapy.  When considering the breadth of contributing inflammatory factors, sepsis is likely to remain an elusive target for therapeutic drug agents.

 

As a result of this therapeutic void, a significant opportunity for non-pharmaceutical blood purification devices has emerged. In this regard, I encourage you to learn about CytoSorbents Corporation and Toray Industries, Inc.  Both are publicly-traded organizations that we highly respect for the advancement of their respective CytoSorb and Toraymyxin devices.  Each of these industry pioneering devices are market cleared and broadly deployed to treat a wide-range of inflammatory conditions outside of the U.S.  They are being clinically evaluated in the U.S. as candidates to treat severe COVID-19 infection under FDA-awarded Emergency Use Authorizations.

 

In regards to mechanism of action, Toraymyxin has a high specificity to bind circulating endotoxin, which is reported to be a potent activator of cytokine storm syndrome. However, the Toraymyxin device does not address pro-inflammatory cytokines. Conversely, the CytoSorb device incorporates an adsorbent component that depletes pro-inflammatory cytokines from circulation, but does not address endotoxin.

 

We designed Sigyn Therapy to deplete the presence of both endotoxin and pro-inflammatory cytokines. To further optimize the potential of our therapeutic outcomes, we expanded Sigyn Therapy’s mechanism to include the elimination of larger proteins that transport cytokines and other inflammatory cargos. We refer to these as CytoVesicles.  To address this breadth of targets, we incorporate a cocktail of adsorbent components within Sigyn Therapy that each have unique binding and capture characteristics. 

 

In the medical field, the term cocktail often refers to the simultaneous administration of multiple drugs with differing mechanisms of action. However, the dosing of multiple drugs is limited by toxicity and adverse events that may result from deleterious drug interactions. Sigyn Therapy is not constrained by such limitations as our cocktail of adsorbent components are not introduced into the body.  As a result, we are able to incorporate a substantial dose of multiple adsorbents, each with differing mechanisms and capabilities to optimize the ability of Sigyn Therapy to calm the cytokine storm that underlies life-threatening inflammatory conditions. 

 

Our therapeutic opportunities include, but are not limited to sepsis, virus induced Cytokine Storm (VICS), bacteria induced Cytokine Storm (BICS), acute respiratory distress syndrome (ARDS) and acute forms of liver failure, including hepatic encephalopathy. 

 

To translate our therapeutic vision into a clinical reality, we are planning a series of studies whose outcomes will be included in an Investigational Device Exemption (IDE) that we intend to submit to FDA in 2021. At present, we are conducting an in vitro study designed to validate the ability of Sigyn Therapy to simultaneously reduce the presence of endotoxin and relevant pro-inflammatory cytokines from human blood plasma. In this study, our cytokine targets include interleukin-6 (IL-6), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-a), which are each drug industry targets to treat COVID-19 infected individuals. 

 

Roche, Sanofi, Regeneron and EUSA Pharma are evaluating anti-IL-6 drugs as COVID-19 treatment candidates.  Additionally, SOBI is testing an IL-1 inhibitor and Amgen is evaluating the potential benefit of Enbrel to inhibit TNF-a in COVID-19 infected individuals.  The prospect of aligning a therapeutic drug with a specific cytokine may be limited as researchers at Stanford and Yale have reported that cytokine profiles in those suffering from severe COVID-19 infection to be consistent with those previously observed in sepsis patients.  We believe that a device with much broader capabilities will be required.

 

I look forward to keeping you updated on our endeavors to advance Sigyn Therapy.

 

Sincerely,

 

Jim Joyce 

Chairman and CEO 

Sigyn Therapeutics, Inc.

 

About Sigyn Therapeutics

Sigyn Therapeutics is a development-stage therapeutic technology company headquartered in San Diego, California USA. Our focus is directed toward a significant unmet need in global health; the treatment of life-threatening inflammatory conditions that are precipitated by Cytokine Storm Syndrome and not addressed with an approved therapy. Our mission is to save lives.

 

Sigyn Therapy™ is a novel blood purification technology designed to mitigate cytokine storm syndrome through the broad-spectrum depletion of inflammatory targets from the bloodstream. Cytokine storm syndrome is the hallmark of sepsis, which is the most common cause of in-hospital deaths and claims more lives each year than all forms of cancer combined. Virus induced cytokine storm (VICS) is associated with high mortality and is a leading cause of SARS-CoV-2 (COVID-19) deaths. Other therapeutic opportunities include, but are not limited to bacteria induced cytokine storm (BICS), acute respiratory distress syndrome (ARDS) and acute forms of liver failure, such as hepatic encephalopathy.

 

To learn more, visit www.SigynTherapeutics.com  or www.SigynTherapy.com

 

Cautionary Note Regarding Forward-Looking Statements

 

This press release contains forward-looking statements of Sigyn Therapeutics, Inc. (“Sigyn”) that involve substantial risks and uncertainties. All statements contained in this press release are forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words “could,” “will,” “plan,” “intend,” “anticipate,” “approximate,” “expect,” “potential,” or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements include, among others, statements about Sigyn’s future financial performance, the impact of management changes, any proposed organizational restructuring, results of operations, capital resources to fund operations; statements about Sigyn’s expectations regarding the capitalization, resources and ownership structure of the combined company; statements about the potential benefits of the transaction; the expected completion and timing of the transaction and other information relating to the transaction; and any other statements other than statements of historical fact. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that Sigyn makes due to a number of important factors, including (i) the risk that the transaction may not be completed in a timely manner or at all, which may adversely affect Sigyn’s business and the price of the common stock of Sigyn, (ii) the failure to satisfy of the conditions to the consummation of the transaction, (iii) the occurrence of any event, change or other circumstance that could give rise to the termination of the merger agreement, (iv) risks related to the ability to realize the anticipated benefits of the transaction, including the risk that the businesses will not be integrated successfully, (v) the effect of the announcement or pendency of the transaction on Sigyn’s business relationships, operating results and business generally, (vi) risks that the proposed transaction disrupts current plans and operations, (vii) risks related to the combined entity’s ability to up-list to a national securities exchange, (viii) risks related to the combined entity’s access to existing capital and fundraising prospects to fund its ongoing operations, (ix) risks related to diverting management’s attention from Sigyn’s ongoing business operations, (x) other business effects, including the effects of industry, market, economic, political or regulatory conditions, future exchange and interest rates, and changes in tax and other laws, regulations, rates and policies, and (xi) the outcome of any legal proceedings that may be instituted against Sigyn related to the merger agreement or the transaction. Further risks that could cause actual results to differ materially from those matters expressed in or implied by such forward-looking statements are discussed in “Risk Factors” and elsewhere in the previous Reign Resources Corporation Quarterly Report on Form 10-Q for the quarter ended June 30, 2020 and other reports filed with the SEC. The forward-looking statements in this press release represent Sigyn’s views as of the date of this press release. Sigyn anticipates that subsequent events and developments may cause its views to change. However, while it may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. You should, therefore, not rely on these forward-looking statements as representing Sigyn’s views as of any date subsequent to the date of this press release.

 

Contact Sigyn Therapeutics, Inc.

Jim Joyce

Chairman, CEO

(619) 368-2000

jimjoyce@elevatescience.com

 

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